Drug information literature evaluation 1 PPT

integration of sound therapeutic principles and evidence-based data to render patient-centered care

Retrieve
Evaluate
Communicate

Drug Information
Biostatistics
and Literature evaluation skills

“The integreation of best research evidence with clinical expertise and patient values”
“The conscientious, explicit, and judicious use of current best evidence in making decisions about the care of individual patients

Explicit, judicious, and conscientious use of current best evidence from medical care research to make decisions about the medical care of individuals

Step 1: Formulating a well-built question
Step 2: Identifying articles and other evidence-based resources that answer the question
Step 3: Critically appraisiing the evidence to assess its validity
Step 4: Applying the evidence
Step 5: Re-evaluation the application of evidence and areas for improvement

P – The patient’s disorder or disease
I – The intervention or finding under review
C – A comparison intervention (if applicable)
O – The Outcome

General information (background) information
Filtered resources
Unfiltered resources

Validity
Clinical Importance
Applicability

– Compare the patient with those in the study
– Consider the patient’s baseline risk for the outcome of interest and other risks associated with therapy
– Consider the patient’s values, beliefs, concerns and readiness for the intervention

– Did I formulate a focused question?
– Did I use the most appropriate resource?
– Did the evidence work in my patient
– Is there new information/data in the literature
– How can I improve and/or update my clinical decisions?
– Reassess the strategy

– Comprehensive searches of the scientific literature
– Critical appraisal of the evidence
– Apply the evidence to individual patients and/or populations

The ability to efficiently search through vast amount, find and critically assess the most pertinent pieces of evidence and apply information to the clinical situation

– To FIND the evidence more efficiently
– To APPRAISE the quality of the evidence more effectively
– To USE good quality evidence more systematically

Provision of information on:
– Drugs/medications/regimens
– Use and place in therapy
– Side effects and management
– Interactions
– Alternatives

– Begun in 1962 – University of Kentucky
– Developed to be a source of “…selected, comprehensive drug information for physicians and dentist to evaluate…”

– Pharm.D. and R.Ph training
– General drug information to practitioners and general public
– Affiliated with university/hospital

– Pharm.D. with residency or experience
– Specific drug information on company products
– Primarily to practitioners only

– University or hospital based service
– Primary focus on suppor tto area practitioners
– Resource for Pharm.D. rotations
– Supports for clinical services
– Pharmacy and Therapeutic committee
– Publication

– Focus on a single product/therapeutic area
– Provides on-label and off-label uses and dosages
– Provides drug monographs and formulary kits
– Audience include clinicians as well as internal customers

– Classify
– Measure
– Analyze
– Interpret
– This is the key to avoiding the use of invalid data form the biomedical literature

– The raw material of Statistics is data
– We may define data as figures. Figures result from the process of counting or from taking a measurement

1. Routinely kept records
2. External sources
3. Surveys
4. Experiments

– Analyze
– Interpret information

Step1: Conduct a Relevance (External Validity) Scan
Step 2: Determine the Intent of the Article
Step 3: Evaluate the Validity of the Research Design
Step 4: Assess Study Methodology and Results (Internal Validity)

– Possessing ability to efficiently search out reliable information
– The ability to critically appraise the information
– Have the ability to apply the information to the situation at hand

Drug information
Biostatistics
Literature Evaluation